Abstract Cisplatin resistance along with chemotherapy-induced neuropathic pain is an important cause of treatment failure for many cancer types and represents an unmet clinical need.Therefore, future studies should provide evidence regarding the mechanisms Chocolate of potential targets that can overcome the resistance as well as alleviate pain.Her
BackgroundLiver steatosis is often observed in chronic HCV infection and associated to Childrens Jacket genotype or comorbidities.NAFLD is an important risk factor for end-stage liver disease.We aimed to analyse the course of NAFLD as a concomitant disease in a cohort of HCV patients.MethodsThe German Hepatitis C-Registry is a national multicenter
An animated interior represents a departure from the idea of interior space as a permanent and timeless entity.The understanding of animated characters in the interior allows for the emergence of our complex relationship with space through various forms of engagement.The understanding of an animated interior offers further possibilities that become
Axon degeneration is a tightly regulated, self-destructive program that is a critical feature of many neurodegenerative diseases, but the molecular mechanisms regulating this program remain poorly understood.Here, we identify S-phase kinase-associated protein 1A (Skp1a), a core component of a Skp/Cullin/F-box (SCF)-type E3 ubiquitin ligase complex,